| ncRNA name | hsa-miR-195 |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal and dermal microvascular endothelial cells (HRECs and HMECs); human embryonic kidney cell line HEK293A |
| Methods | RT-PCR, transfection, luciferase reporter assay, in situ hybridisation, immunohistochemistry, Western blot |
| Expression pattern | up-regulated |
| Functional description | A luciferase assay confirmed the binding of miR-195 to the 3' untranslated region of SIRT1. miR-195 expression was upregulated in retinas of diabetic rats and intravitreal injection of miR-195 antagomir ameliorated levels of SIRT1. |
| PubMed ID | 24570140 |
| Year | 2014 |
| Title | miR-195 regulates SIRT1-mediated changes in diabetic retinopathy. |
| Drug-related ncRNA | NO |
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